Grey’s Anatomy,has cemented itself into pop culture history.

Before long,Grey’s Anatomygained a reputation for killing or writing off main characters during major episodes.

Here are the real reasons why these stars leftGrey’s Anatomy.

Patrick Dempsey as Dr. Derek Sheperd in Grey’s Anatomy

But in 2006, rumors began to circulate that Washington had caused some trouble behind the scenes.

During an argument with co-star Patrick Dempsey, Washington reportedly used a homophobic slur (viaPeople).

Not long afterwards, his co-star T.R.

Isaiah Washington on Grey’s Anatomy

Knight revealed toPeoplethat he is gay, causing Washington to face even more backlash for his alleged words.

I’d slept with numerous people at the hospital.

I was like, ‘What else can I do?’

Grey’s Anatomy star Kate Walsh

other than start like making lunch for everybody."

Grey’s Anatomy actor T.R.

Knight may have butted heads with Shonda Rhimes

After Brooke Smith came T.R.

Grey’s Anatomy star Brooke Smith

Knight, who played the beloved character George O’Malley.

Instead, he just asked to leave.

It wasn’t the first time Rhimes and Knight seemed to disagree.

Grey’s Anatomy star T.R. Knight

Knight the best in his future endeavors."

Heigl gave a statement toEntertainment Weekly(viaE!

News), saying, “I am done,” noting, “We just finalized our agreement.

Grey’s Anatomy star Katherine Heigl

Everyone had been working really hard to find an amicable and gracious way of letting go and moving on.

It’s sad but it’s what I wanted.”

Apparently, however, that decision was all on Leigh.

Grey’s Anatomy Chyler Leigh

In a statement given toE!

My experience onGrey’s Anatomyis something that I will treasure for the rest of my life."

Shonda Rhimestweetedabout Leigh leaving, saying, “I love Chyler and I love the character of Lexie Grey.

Grey’s Anatomy star Kim Raver

She was an important member of myGrey’sfamily.

This was not an easy decision.

But it was a decision that Chyler and I came to together.

Grey’s Anatomy star Eric Dane

As it turns out, that may have been exactly what she was doing while she was gone.

Dane, who played Dr. Mark Sloan, said he himself made the decision to leave the series.

However, Dane noted, “I loved doing Grey’s Anatomy.

Grey’s Anatomy star Sandra Oh

Unfortunately, seems like Ferrer and Charles' contracts were not renewed past the tenth season.

Neither actor released any statements about the news of their departures.

The series was never picked up, and Hinton ended up taking a role on an HBO show.

Grey’s Anatomy stars Gaius Charles and Tessa Ferrar

In my mind it’s been left open-ended enough.”

As for Martin, this is not an ending for our relationship.”

We talked and she ran it down for me and had me at hello."

Grey’s Anatomy star Patrick Dempsey

According to aDeadlinereport, the decision was made by producers.

Drew also released a statement on her own Instagram account.

I am so humbled and so thankful."

Grey’s Anatomy star Sara Ramirez

But according to an ABC source, it wasn’t just George’s decision.

“Melissa’s arc came to a natural end,” they said.

“Everyone at the show adores her.

Grey’s Anatomy star Jerrika Hinton

I’m not old enough for this!

“The contracts are coming up, they’re getting ready to go into the second season of that.

So all of that is in the air,” she said.

Grey’s Anatomy star Martin Henderson

It’s so hard to stay current in this business or to stay in the business, period.”

I’m still not over it.

It broke my heart to leave that show."

Grey’s Anatomy star Jason George

In fact, between 2006 and 2011, actor Jeff Perry only appeared onGrey’s Anatomy14 times.

Still, for Perry, coming back forone final episodein 2019 felt like his character was finally getting closure.

He toldPeople, “Actors are weird creatures.

Grey’s Anatomy stars Jessica Capshaw and Sarah Drew

Unlike more sane humans, we seem to enjoy going into the territory that is shaky and most vulnerable.

…So, I was really excited by the thought to get to the unresolved.”

The actor was also excited to step back into the Shondaland world.

Grey’s Anatomy star Melissa George

He said the experience was “great and deeply comfortably [sic].”

Like Perry, Foley went on to co-star inScandal, a role he toldRedditwas more satisfying to film.

Chambers continued, revealing that he’d wanted to “diversify” his acting career for a while.

Grey’s Anatomy star Loretta Devine

Grey’s Anatomy star Jeffrey Dean Morgan

Grey’s Anatomy star Jeff Perry

Grey’s Anatomy star Scott Foley

Justin Chambers as Dr. Alex Karev on Grey’s Anatomy