Few shows have the heart-wrenching capabilities thatGrey’s Anatomydoes.
And, as avid fans will tell you, each relationship served a purpose.
Others had intense physical chemistry, and some were just plain soulmates.
Grey’s Anatomyhas a tendency to keep viewers on their toes when it comes to its romances.
So here are the best and worst couples onGrey’s Anatomy(warning: spoilers ahead.)
Dempsey echoed the sentiment, saying that coming back was “very special.”
Here’s to hoping that theGrey’swriting team finds a way to bring these two back together for real.
But their marriage was doomed from the start.
At one point, Izzie even thought that Callie wanted to physically fight her over George!
Cue Rachel’s line fromFriends:“Once a cheater, always a cheater.”
That’s exactly howCristina and Owen met, and thus began their rocky relationship.
They also fought constantly about having children, and even after their divorce, continued sleeping together.
She eventually moved away from Seattle leaving Owen there to figure out his life.
But we sure did love them together.
Their time as a couple was so messy thatBustleactually put together a timeline of their drama.
Not dissimilar to Owen’s problems with Cristina, the couple disagreed on children.
Their ensuing breakup was one ofGrey’s Anatomy’s most heartbreaking moments.
These two were soulmates, and despite their rocky relationship, they were destined to be together.
But like many of the best couples inGrey’s, Mark and Lexie broke up when things got complicated.
Then, after their break up, they both dated other people.
And when Mark got together with Julia, it seemed like their relationship was doomed.
For those of you who are bingingGrey’s Anatomy,stop reading here.
But reliving their relationship still hurts the heart on a lot of levels.
We’re just really glad that Alex was able to move on from this one.
Sheclearlyhad unresolved feelings for him, because she left her fiance and ran off with Jackson into the sunset.
For a while, April and Jackson’s relationship seemed hopeful, but things ultimately got complicated.
April and Jackson eventually got divorced even though April was once again pregnant.
So yes, things got super awkward after that.
But the relationship between Callie and Penny was also unhealthy for a number of reasons.
But when Izzie was diagnosed with cancer, their relationship took on a whole new meaning.
To distract herself, Izzie threw herself into planning Meredith and Derek’s wedding.
The wedding was beautiful, and anyGrey’sfan who says they didn’t cry while watching it is lying.
Izzie and Alex’s relationship eventually ended whenKatherine Heigl leftGrey’s Anatomyafter season 6.
But when Alex finally departed in season 16, fans learn he’d rejoined Izzie and his children.
Needless to say, these two were destined to be together.
From that moment on, Callie and Arizona consistently fought.
Arizona even ended up having an affair with another doctor.
It became one of the worst relationships onGrey’s Anatomy, especially given everything that they’d been through.
Things started to look up when the Callie and Arizona tried to put their differences aside.
They bought a house together, tried to have a second baby, and started going to therapy.
But their efforts fell short and they eventually got divorced.
As noted byBustle,Bailey fully chewed Ben out for what she thought was his mistake.
However, the patient turned out to have a strange condition that impacted her sensitivity to anesthesia.
It’s safe to say that these two are one ofGrey’s Anatomy’s best couples.
Worst: Richard and Ellis’s relationship had significant fallout
Things were already complicated beforeGrey’s Anatomybegan.
Richard and Ellis dated, even though both of them were married to other people.
Denny was a heart transplant patient at Seattle Grace, and Izzie started caring for him as a doctor.
And of course, the nail in the coffin was when Burke literally left her on their wedding day.
