Jackson asked his ex.
“I knew it would, but you didn’t want to stay with me,” April responded.
Talk about a heart-breaking moment.
I don’t want this."
He then admitted he’d choose his daughter over her.
Of course, for those of you who areGrey’ssuper-fans, you know what happened in Season 8.
Mark and Lexie, accompanied by the other doctors of Seattle Grace Hospital, suffered a devastating plane crash.
Lexie died from her injuries, and Mark passed away shortly after.
“you’ve got the option to’t die because we’re supposed to end up together.
We’re meant to be,” Marksaid to heras she died.
This marked one ofGrey’s Anatomy’s most heartbreaking moments.
She decided to follow him and ended up in Seattle where they tried to give their marriage another shot.
As a result, their marriage ended.
So when Derek and Addison finally admitted that their union is over, the moment was truly crushing.
Moment even more ruined.
Gotta loveGrey’s Anatomy.
“My husband informed me yesterday that if I accept the peds fellowship … he will divorce me.
It’s abigdecision,” she said, before walking away.
It’s a moment that stuck with a lot ofGrey’sfans given that Bailey had always been so in control.
So even though the breakup itself wasn’t seen on screen, the devastating shockwaves were felt tenfold.
So when Burke asked Cristina to marry him, it was truly such a good moment.
But the couple delivered one of theworstbreakups inGrey’shistory.
I would be letting you go."
Like come on, why did he do that to us!
“I’m sure she’s really great.
But Derek, I love you … so pick me, choose me, love me.”
But their happiness was short-lived.
Izzie was diagnosed with cancer, and Alex stayed by her side throughout (viaElite Daily).
They even got married, though it was rushed, giving Izzie the perfect wedding day despite her illness.
“I know now that I’m good enough not to deserve this,” Alex said.
“Not to feel like this not to love you so much that I almost hate you.
I deserve someone who will stay.”
Especially given that hemarried Callie(who, yes, became Callie O’Malley) sort of on a whim.
“What I did to you is unforgivable,” George started off.
It was the ending that we all could have predicted, but it still hurt to watch.
They met back in the early years of their careers and had some devastating ups and downs.
“I’m sorry, I can’t,” Richard said.
“Richard, you could’t leave me,” Ellis responded, before begging for him to stay.
All the while, a young Meredith rode the carousel, witnessing the whole situation unfold.
Meredith later recalled that after Richard ended their relationship, Ellis tried to take her own life.
“Everything after that was my fault,” Richard confessed to Meredith.
Talk about a heartbreak from start to finish.
“You are perfect,” she said to Ben.
“But I’m busy holding myself together with tape and glue.”
Ugh, talk about having to break out the tissues.
But it still hurts every time we watch it.
The couple were on again, off again, and then on again more times than we could count.
“Am I enough, Owen?”
she asked him inSeason 9’s finale.
“Do you really believe I’ll be enough?”
In his silence was the answer that Cristina needed to hear.
“It already happened,” Cristina eventually said, and she left.
Owen and Cristina went through so much in their relationship that this breakup was especially hard to watch.
They had one of his most consistent relationships throughout the show.
So their breakup was beyond devastating because so many of us thought they were meant to be.
But Alex found out that Izzie, who had frozen their embryos, had given birth to his kids.
“You deserve more than a letter,” he wrote.
“This cowardice, this letter it’s officially the worst thing I’ve ever done.”
And that’s saying a lot given that Alex did some pretty terrible things.
Owen had fought PTSD throughout the show, and Amelia was a recovering addict.
“I just want us to be happy,” he continued.
“It’s ok, Owen.
I know,” Amelia said.
