Some details about the series premiere ofGrey’s Anatomyare so tiny that they’re easy to gloss over.

Warning: there are somemajorspoilers ahead.

It also kicked off a long-running tradition on the show to name episodes after song titles.

Meredith on Grey’s Anatomy

However, while shooting first episode of the show, one important character wasn’t actually there.

How could such an important person have been omitted from the first episode?

It turns out that Alex wasn’t even part of the initial shoot forGrey’s Anatomy’s first episode.

Grey’s Anatomy

Added the actor, “It worked out.”

However, it’s also kicked off the careers of some of its more minor characters.

It was a small role for Ramamurthy, but much bigger things were in his future.

Meredith on Grey’s Anatomy

The year after the first episode ofGrey’s Anatomyaired, he landed a starring role onHeroesplaying Mohinder Suresh.

However, perhaps the most important relationship of the show is the friendship between Meredith Grey and Cristina Yang.

Webber’s pride in Meredith and her abilities also foreshadows the relationship the two share later in the series.

Meredith in Grey’s Anatomy

We love Derek Shepherd (a.k.a.

When she says no, he continues to pressure her.

Derek Shepherd isn’t the only person who falls for Meredith Grey in the first episode ofGrey’s Anatomy.

Alex on Grey’s Anatomy

In fact, theyseem to think he’s gay.

Meredith’s alma mater is more than just a hidden detail about the character, though.

Rhimes graduated from the prestigious schoolin 1991, and evenreturned in 2014to deliver a commencement speech.

Sendhil Ramamurthy on Grey’s Anatomy

Did George O’Malley foreshadow his own death in the first episode of Grey’s Anatomy?

However, his words later take on a whole new meaning.

Meredith and Cristina on Grey’s Anatomy

Richard Webber on Grey’s Anatomy

Derek on Grey’s Anatomy

Derek on Grey’s Anatomy

George on Grey’s Anatomy

Meredith on Grey’s Anatomy

Meredith on Grey’s Anatomy

George on Grey’s Anatomy

Katie Bryce on Grey’s Anatomy